Article
The Marburg I variant (G534E) of the factor VII-activating protease determines liver fibrosis in hepatitis C infection by reduced proteolysis of platelet-derived growth factor BB.
Hepatology (Baltimore, Md.) - 1 Mar 2009
Wasmuth Hermann E, Tag Carmen G, Van de Leur Eddie, Hellerbrand Claus, Mueller Tobias, Berg Thomas, Puhl Gero, Neuhaus Peter, Samuel Didier, Trautwein Christian, Kanse Sandip M, Weiskirchen Ralf
Abstract excerpt
UNLABELLED: Genetic risk factors play an important role for the progression of liver fibrosis in chronic hepatitis C virus (HCV) infection, but functional data on specific alleles and their related proteins are limited. Platelet-derived growth factor BB (PDGF-BB) is one of the strongest mitogens for hepatic stellate cells and is considered as a critical soluble mediator of liver fibrosis in vitro and in vivo. The...
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