Article
ADAMTS4 elicits myeloid-derived immune cell recruitment and liver fibrogenesis in metabolic dysfunction-associated steatotic liver disease.
Signal transduction and targeted therapy - 6 May 2026
Park Jeongwoo, Kim Taeeung, Shim Wan Seob, Hong Sung Eun, Park Miso, Oh Seungseok, Koo Bo Kyung, Lee Dong Hyeon, Joo Sae Kyung, Yoo Taekyeong, Lee Young Joo, Lim Sung-Chul, Seo Seung-Yong, Kim Kyu Min, Nieto Natalia, Choi Murim, Kim Won, Kang Keon Wook
Abstract excerpt
A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) has been implicated in arthritis and lung fibroblast activation; however, its role in liver homeostasis and fibrogenesis remains largely unexplored. Here, we investigated the functional significance of ADAMTS4 in liver fibrosis. We found that hepatic ADAMTS4 mRNA expression was significantly elevated in patients with fibrotic...
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