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Article

The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity.

Thrombosis research - 1 Dec 2012

Etscheid M, Muhl L, Pons D, Jukema J W, König H, Kanse S M

Abstract excerpt

INTRODUCTION: Factor VII activating protease (FSAP) is a plasma protease with FVII and pro-urokinase (pro-uPA) activating properties. A single nucleotide polymorphism (SNP) (Marburg I, MI) in the FSAP gene (HABP-2) leads to a low activity of the MI-FSAP towards pro-uPA, but supposedly not towards FVII and is described as a risk factor for athero-thrombosis and liver fibrosis. Recently we found, however, that FVII...

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Source

Identifiers

PMID: 22906531
DOI: 10.1016/j.thromres.2012.07.023

Genes

TFPI

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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