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Fibroblast activation protein-α in fibrogenic disorders and cancer: more than a prolyl-specific peptidase?

22 Aug 2017

Abstract excerpt

INTRODUCTION: Fibroblast activation protein-α (FAP-α) belongs to the family of prolyl-specific serine proteases. FAP-α displays both exopeptidase and endopeptidase/gelatinase/collagenase activities. FAP-α protein and/or activity have been associated with fibrosis, inflammation and cancer, but the protein is undetectable in most normal tissues. FAP-α is selectively expressed at sites of tissue remodeling and...

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PMID: 28829211
DOI: 10.1080/14728222.2017.1370455

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