Article
The development and characterization of encephalitogenic cloned T cells specific for myelin proteolipid protein.
Journal of neuroimmunology - 1 Feb 1990
van der Veen R C, Trotter J L, Hickey W F, Kapp J A
Abstract excerpt
T-cell clones have been isolated from SJL/J mice after immunization with myelin proteolipid protein (PLP). The cloned cells responded strongly to PLP stimulation in vitro as well as to the synthetic PLP-related peptide 139-151. The response to PLP is Ia mediated, since it was inhibited by monoclonal antibodies to the matched I-As haplotype, but not with antibodies to other I-A haplotypes. Phenotypic analysis...
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