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Article

Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis.

Proceedings of the National Academy of Sciences of the United States of America - 26 Oct 2004

Reddy Jayagopala, Illes Zsolt, Zhang Xingmin, Encinas Jeffrey, Pyrdol Jason, Nicholson Lindsay, Sobel Raymond A, Wucherpfennig Kai W, Kuchroo Vijay K

Abstract excerpt

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE are associated with a high precursor frequency of PLP 139-151-specific T cells in the naive repertoire of SJL mice. To understand the mechanism of EAE resistance in B10.S mice, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

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Identifiers

PMID: 15492218
DOI: 10.1073/pnas.0404444101
PMCID: PMC524444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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