Article
Recognition of self class II major histocompatibility complex antigens by CD8+ T cell clones derived from rheumatoid arthritis synovial membrane.
Autoimmunity - 1 Jan 1990
Gaston J S, Solovera J, Strober S
Abstract excerpt
T cells from rheumatoid synovium have been expanded in vitro as lines and clones using autologous Epstein-Barr virus-transformed stimulator cells. Both lines and clones recognized autologous class II MHC antigens in the absence of defined exogenous antigens i.e. the equivalent of the autologous mixed lymphocyte response. Surprisingly, despite their MHC specificity, several clones expressed CD8 rather than CD4,...
Topics
- Antigen-Presenting Cells
- Antigens, Differentiation, T-Lymphocyte
- Arthritis, Rheumatoid
- CD4 Antigens
- CD8 Antigens
- Cell Division
- Cell Survival
- Clone Cells
- HLA-DR2 Antigen
- HLA-DR5 Antigen
- Histocompatibility Antigens Class II