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Article

Treatment of Experimental Autoimmune Encephalomyelitis with Genetically Modified Memory T Cells

7 Jul 1997

Abstract excerpt

The migratory properties of memory T cells provide a model vector system for site-specific delivery of therapeutic transgene factors to autoimmune inflammatory lesions. Lymph node cells from (SWRxSJL)F1 mice immunized with the p139-151 determinant of myelin proteolipid protein (PLP) were transfected with a DNA construct that placed the anti-inflammatory cytokine interleukin-10 (IL-10) cDNA under control of an...

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Identifiers

PMID: 9207010
DOI: 10.1084/jem.186.1.159

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