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Article

Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.

The Journal of cell biology - 1 Feb 1990

Jing S Q, Spencer T, Miller K, Hopkins C, Trowbridge I S

Abstract excerpt

Wild-type and mutant human transferrin receptors have been expressed in chicken embryo fibroblasts using a helper-independent retroviral vector. The internalization of mutant human transferrin receptors, in which all but four of the 61 amino acids of the cytoplasmic domain had been deleted, was greatly impaired. However, when expressed at high levels, such "tailless" mutant receptors could provide chicken embryo...

Topics

Amino Acid Sequence
Amino Acids
Animals
Cell Division
Chick Embryo
Cytoplasm
Endocytosis
Fibroblasts
Humans
Immunohistochemistry
Iron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Sorting Signals

Receptors, Transferrin

Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 2298808
DOI: 10.1083/jcb.110.2.283
PMCID: PMC2116009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2298808-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Role of the human transferrin receptor cytoplasmic domain in endocytosis: localization of a specific signal sequence for internalization.PMID 2298808Read ↗

A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.Semantic proximity Read ↗

Mutational analysis of the cytoplasmic tail of the human transferrin receptor. Identification of a sub-domain that is required for rapid endocytosis.Semantic proximity Read ↗

Mutagenesis of the human transferrin receptor: two cytoplasmic phenylalanines are required for efficient internalization and a second-site mutation is capable of reverting an internalization-defective phenotype.Semantic proximity Read ↗

Nonacylated human transferrin receptors are rapidly internalized and mediate iron uptake.Semantic proximity Read ↗

Localization of the signal for rapid internalization of the bovine cation-independent mannose 6-phosphate/insulin-like growth factor-II receptor to amino acids 24-29 of the cytoplasmic tail.Semantic proximity Read ↗

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