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Article

A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.

The Biochemical journal - 1 Apr 1990

Alvarez E, Gironès N, Davis R J

Abstract excerpt

The rate of receptor-mediated endocytosis of diferric 125I-transferrin by Chinese-hamster ovary cells expressing human transferrin receptors was compared with the rate measured for cells expressing hamster transferrin receptors. It was observed that the rate of endocytosis of the human transferrin receptor was significantly higher than that for the hamster receptor. In order to examine the molecular basis for the...

Topics

Amino Acid Sequence
Animals
Cell Line
Cricetinae
Cysteine
Cytoplasm
DNA
Endocytosis
Gene Expression
Humans
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Transferrin

Sequence Homology, Nucleic Acid

Structure-Activity Relationship

Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 2327986
DOI: 10.1042/bj2670031
PMCID: PMC1131239

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2327986-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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A point mutation in the cytoplasmic domain of the transferrin receptor inhibits endocytosis.PMID 2327986Read ↗

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