Article
MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators.
Genes & development - 1 Dec 2013
Lee Jongmin, Reiter Wolfgang, Dohnal Ilse, Gregori Christa, Beese-Sims Sara, Kuchler Karl, Ammerer Gustav, Levin David E
Abstract excerpt
The aquaglyceroprin Fps1 is responsible for glycerol transport in yeast in response to changes in extracellular osmolarity. Control of Fps1 channel activity in response to hyperosmotic shock involves a redundant pair of regulators, Rgc1 (regulator of the glycerol channel 1) and Rgc2, and the MAPK...
Topics
- Membrane Proteins
- Mitogen-Activated Protein Kinases
- Mutation
- Osmotic Pressure
- Phosphorylation
- Protein Binding
- Protein Structure, Tertiary
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins