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Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells.

Free radical biology & medicine - 15 Nov 2012

Ribeiro Márcio, Rosenstock Tatiana R, Cunha-Oliveira Teresa, Ferreira Ildete L, Oliveira Catarina R, Rego A Cristina

Abstract excerpt

Huntington's disease (HD) is a CAG repeat disorder affecting the HD gene, which encodes for huntingtin (Htt) and is characterized by prominent cell death in the striatum. Oxidative stress was previously implicated in HD neurodegeneration, but the role of the major endogenous antioxidant system, the glutathione redox cycle, has been less studied following expression of full-length mutant Htt (FL-mHtt). Thus, in...

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PMID: 22982598
DOI: 10.1016/j.freeradbiomed.2012.09.004

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