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Article

Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease.

Brain : a journal of neurology - 1 Oct 2015

Hong Chansik, Seo Hyemyung, Kwak Misun, Jeon Jeha, Jang Jihoon, Jeong Eui Man, Myeong Jongyun, Hwang Yu Jin, Ha Kotdaji, Kang Min Jueng, Lee Kyu Pil, Yi Eugene C, Kim In-Gyu, Jeon Ju-Hong, Ryu Hoon, So Insuk

Abstract excerpt

Aberrant glutathione or Ca(2+) homeostasis due to oxidative stress is associated with the pathogenesis of neurodegenerative disorders. The Ca(2+)-permeable transient receptor potential cation (TRPC) channel is predominantly expressed in the brain, which is sensitive to oxidative stress. However, the role of the TRPC channel in neurodegeneration is not known. Here, we report a mechanism of TRPC5 activation by...

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Source

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Identifiers

PMID: 26133660
DOI: 10.1093/brain/awv188
PMCID: PMC4643628

Genes

TRPC5
TRPC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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