Article
Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation.
Neurochemistry international - 1 Jul 2018
Vidoni Chiara, Secomandi Eleonora, Castiglioni Andrea, Melone Mariarosa A B, Isidoro Ciro
Abstract excerpt
Parkinsonian-like motor deficits in Huntington's Disease (HD) patients are associated with abnormal dopamine neurotransmission in the striatum. Dopamine metabolism leads to the formation of oxidized dopamine quinones that exacerbates mitochondrial dysfunction with production of reactive oxygen species (ROS) that eventually lead to neuronal cell death. We have previously shown that dopamine-induced oxidative...
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