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Article

Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL.

Journal of lipid research - 1 Feb 2013

Kim Daniel S, Burt Amber A, Crosslin David R, Robertson Peggy D, Ranchalis Jane E, Boyko Edward J, Nickerson Deborah A, Furlong Clement E, Jarvik Gail P

Abstract excerpt

HDL-associated paraoxonase 1 (PON1) activity is associated with cardiovascular and other human diseases. As the role of genetic variants outside of the PON gene cluster on PON1 activity is unknown, we sought to identify common and rare variants in such loci. We typed 33,057 variants on the CVD chip in 1,362 subjects to test for their effects on adjusted-PON1 activity. Three novel genes (FTO, ITGAL, and SERPINA12)...

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Source

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Identifiers

PMID: 23160181
DOI: 10.1194/jlr.P033266
PMCID: PMC3588879

Genes

PON1
SERPINA12
FTO
ITGAL
PON3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL.PMID 23160181Read ↗

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