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Article

A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Dec 2012

Suter Melissa A, Chen Aishe, Burdine Marie S, Choudhury Mahua, Harris R Alan, Lane Robert H, Friedman Jacob E, Grove Kevin L, Tackett Alan J, Aagaard Kjersti M

Abstract excerpt

In nonhuman primates, we previously demonstrated that a maternal high-fat diet (MHFD) induces fetal nonalcoholic fatty liver disease (NAFLD) and alters the fetal metabolome. These changes are accompanied by altered acetylation of histone H3 (H3K14ac). However, the mechanism behind this alteration...

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Source

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Identifiers

PMID: 22982377
DOI: 10.1096/fj.12-212878
PMCID: PMC3509051

Genes

SIRT1
FASN
PPARG
SCD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22982377-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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