Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.

International journal of biological sciences - 16 Nov 2010

Wang Rui-Hong, Li Cuiling, Deng Chu-Xia

Abstract excerpt

SIRT1, a homolog of yeast Sir2, is a type III NAD(+) dependent histone and protein deacetylase. Previous studies of mice carrying liver specific deletion of exon 4 of the Sirt1 gene revealed opposite responses of mutant mice to a high-fat diet in terms of fatty liver formation, which obscures the function of SRIT1 in liver development and lipid metabolism. To investigate this, we deleted exons 5 and 6 of Sirt1 in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

Share to Fatty Liver

Share to Mice, Knockout

Share to Nuclear Proteins

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sirtuin 1

Source

Open in PubMed Open full text

Identifiers

PMID: 21103071
DOI: 10.7150/ijbs.6.682
PMCID: PMC2990071

Genes

SIRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Liver steatosis and increased ChREBP expression in mice carrying a liver specific SIRT1 null mutation under a normal feeding condition.PMID 21103071Read ↗

Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation.Semantic proximity Read ↗

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.Semantic proximity Read ↗

Involvement of SIRT1-mediated aging in liver diseasesSemantic proximity Read ↗

The role of sirtuin1 in liver injury: molecular mechanisms and novel therapeutic targetSemantic proximity Read ↗

Hepatic SIRT6 deficit promotes liver tumorigenesis in the mice modelsSemantic proximity Read ↗

Resveratrol treatment improves plasma and blood glucose concentration and lipid metabolism in high-fat-fed C57BL/6J miceSemantic proximity Read ↗

Identification of a Tissue-Restricted Isoform of SIRT1 Defines a Regulatory Domain that Encodes SpecificitySemantic proximity Read ↗

Reduced mitochondrial function in obesity-associated fatty liver: SIRT3 takes on the fat.Semantic proximity Read ↗

High calorie diet background alters the expression of sirtuins in the testes of mice under caloric restrictionSemantic proximity Read ↗

Sirtuin-6–Dependent Genetic And Epigenetic Alterations Are Associated With Poor Clinical Outcome in Hepatocellular Carcinoma PatientsSemantic proximity Read ↗

Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.Semantic proximity Read ↗

SIRT1 Disruption in Human Fetal Hepatocytes Leads to Increased Accumulation of Glucose and LipidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.