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Mammalian ABC Transporters in Health and Disease

1 Jun 2002

Abstract excerpt

The ATP-binding cassette (ABC) transporters are a family of large proteins in membranes and are able to transport a variety of compounds through membranes against steep concentration gradients at the cost of ATP hydrolysis. The available outline of the human genome contains 48 ABC genes; 16 of these have a known function and 14 are associated with a defined human disease. Major physiological functions of ABC...

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PMID: 12045106
DOI: 10.1146/annurev.biochem.71.102301.093055

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