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Article

A novel NADH kinase is the mitochondrial source of NADPH in Saccharomyces cerevisiae.

The EMBO journal - 1 May 2003

Outten Caryn E, Culotta Valeria C

Abstract excerpt

Mitochondria require NADPH for anti-oxidant protection and for specific biosynthetic pathways. However, the sources of mitochondrial NADPH and the mechanisms of maintaining mitochondrial redox balance are not well understood. We show here that in Saccharomyces cerevisiae, mitochondrial NADPH is largely provided by the product of the POS5 gene. We identified POS5 in a S.cerevisiae genetic screen for...

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Identifiers

PMID: 12727869
DOI: 10.1093/emboj/cdg211
PMCID: PMC156083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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