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Article

Genotypes in relation to phenotypic appearance and exposure to environmental factors in Graves' hyperthyroidism.

European journal of endocrinology - 1 Dec 2012

Vos Xander G, Endert Erik, Tijssen Jan G P, Wiersinga Wilmar M

Abstract excerpt

BACKGROUND: Genetic polymorphisms and environmental factors are both involved in the pathogenesis of Graves' disease, but their interaction and effect on Graves' phenotypes have scarcely been investigated. OBJECTIVE: To test the hypothesis that subjects with susceptibility genotypes develop more severe Graves' hyperthyroidism at a younger age and after less exposure to environmental factors, with attention to...

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Source

Identifiers

PMID: 22968483
DOI: 10.1530/EJE-12-0651

Genes

CTLA4
PTPN22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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