Article
Phorbol ester induces photoreceptor-specific degeneration in a Drosophila mutant.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1990
Minke B, Rubinstein C T, Sahly I, Bar-Nachum S, Timberg R, Selinger Z
Abstract excerpt
In the retinal degeneration B (rdgB) mutant of Drosophila, the major class of photoreceptors degenerate when the fly is raised in the light for several days; raising the fly in the dark largely prevents the degeneration. Thus, the rdgB is a conditional mutant that requires the operation of some stages of the phototransduction cascade to express its characteristic phenotype. We report here experiments that examine...
Topics
- Animals
- Drosophila
- GTP Phosphohydrolases
- Microscopy, Electron
- Mutation
- Phorbol Esters
- Photoreceptor Cells
- Protein Kinase C
- Retinal Degeneration
- Signal Transduction