Article
A G protein-coupled receptor phosphatase required for rhodopsin function.
Science (New York, N.Y.) - 1 Aug 1997
Vinós J, Jalink K, Hardy R W, Britt S G, Zuker C S
Abstract excerpt
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors are phosphorylated by kinases that mediate agonist-dependent receptor deactivation. Although many receptor kinases have been isolated, the corresponding phosphatases, necessary for restoring the ground state of the receptor, have not been identified. Drosophila RDGC (retinal degeneration C) is a phosphatase required for rhodopsin...
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