Article
Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males.
BMC urology - 10 Sept 2012
Nagarkatti-Gude David R, Collodel Giulia, Hill Lori D, Moretti Elena, Geminiani Michela, Zhang Zhibing, Strauss Jerome F
Abstract excerpt
BACKGROUND: SPAG16 is a critical structural component of motile cilia and flagella. In the eukaryotic unicellular algae Chlamydomonas, loss of gene function causes flagellar paralysis and prevents assembly of the "9 + 2" axoneme central pair. In mice, we have previously shown that loss of Spag16 gene function causes male infertility and severe sperm motility defects. We have also reported that a heterozygous...
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