Article
Patients with severe asthenoteratospermia carrying SPAG6 or RSPH3 mutations have a positive pregnancy outcome following intracytoplasmic sperm injection.
Journal of assisted reproduction and genetics - 1 Apr 2020
Wu Huan, Wang Jiajia, Cheng Huiru, Gao Yang, Liu Wangjie, Zhang Zhiguo, Jiang Huanhuan, Li Weiyu, Zhu Fuxi, Lv Mingrong, Liu Chunyu, Tan Qing, Zhang Xiaofeng, Wang Chao, Ni Xiaoqing, Chen Yujie, Song Bing, Zhou Ping, Wei Zhaolian, Zhang Feng, He Xiaojin, Cao Yunxia
Abstract excerpt
PURPOSE: To investigate the relation between mutations in ciliopathy-related SPAG6 and RSPH3 and male infertility with severe asthenoteratospermia characterized by multiple flagellar malformations and reveal the intracytoplasmic sperm injection (ICSI) outcomes of those primary ciliary dyskinesia (PCD) patients. METHODS: Whole-exome sequencing was applied to identify the pathogenic genes for the five PCD patients....
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