Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme.

Biology of reproduction - 1 Nov 2007

Zhang Zhibing, Zariwala Maimoona A, Mahadevan Maha M, Caballero-Campo Pedro, Shen Xuening, Escudier Estelle, Duriez Bénédicte, Bridoux Anne-Marie, Leigh Margaret, Gerton George L, Kennedy Marcus, Amselem Serge, Knowles Michael R, Strauss Jerome F

Abstract excerpt

The SPAG16 gene encodes two major transcripts, one for the 71-kDa SPAG16L, which is the orthologue of the Chlamydomonas rheinhardtii central apparatus protein PF20, and a smaller transcript, which codes for the 35-kDa SPAG16S nuclear protein that represents the C-terminus (exons 11-16) of SPAG16L...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axoneme
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterozygote

Share to Microtubule-Associated Proteins

Share to Microtubule Proteins

Share to Mutagenesis, Insertional

Share to Sperm Motility

Share to Spermatozoa

Source

Identifiers

PMID: 17699735
DOI: 10.1095/biolreprod.107.063206

Genes

SPAG16
SPAG6
SPAG17

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17699735-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A heterozygous mutation disrupting the SPAG16 gene results in biochemical instability of central apparatus components of the human sperm axoneme.PMID 17699735Read ↗

Genetic variation in SPAG16 regions encoding the WD40 repeats is not associated with reduced sperm motility and axonemal defects in a population of infertile males.Semantic proximity Read ↗

Deficiency of SPAG16L Causes Male Infertility Associated with Impaired Sperm Motility1Semantic proximity Read ↗

A novel hypomorphic allele of <i>Spag17</i> causes primary ciliary dyskinesia phenotypes in miceSemantic proximity Read ↗

A novel hypomorphic allele of Spag17 causes primary ciliary dyskinesia phenotypes in mice.Semantic proximity Read ↗

SPAG17 Is Required for Male Germ Cell Differentiation and FertilitySemantic proximity Read ↗

Homozygous mutation in SPATA16 is associated with male infertility in human globozoospermia.Semantic proximity Read ↗

Male infertility, impaired sperm motility, and hydrocephalus in mice deficient in sperm-associated antigen 6.Semantic proximity Read ↗

Human Globozoospermia-Related Gene Spata16 Is Required for Sperm Formation Revealed by CRISPR/Cas9-Mediated Mouse ModelsSemantic proximity Read ↗

cDNA Cloning and Characterization of a Human Sperm Antigen (SPAG6) with Homology to the Product of the Chlamydomonas PF16 LocusSemantic proximity Read ↗

SPAG17 mediates nuclear translocation of protamines during spermiogenesisSemantic proximity Read ↗

Sperm Antigen 6 Is the Murine Homologue of the Chlamydomonas reinhardtii Central Apparatus Protein Encoded by the PF16 Locus1Semantic proximity Read ↗

Sperm-associated antigen-17 gene is essential for motile cilia function and neonatal survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.