Article
PARADIGM-SHIFT predicts the function of mutations in multiple cancers using pathway impact analysis.
Bioinformatics (Oxford, England) - 15 Sept 2012
Ng Sam, Collisson Eric A, Sokolov Artem, Goldstein Theodore, Gonzalez-Perez Abel, Lopez-Bigas Nuria, Benz Christopher, Haussler David, Stuart Joshua M
Abstract excerpt
MOTIVATION: A current challenge in understanding cancer processes is to pinpoint which mutations influence the onset and progression of disease. Toward this goal, we describe a method called PARADIGM-SHIFT that can predict whether a mutational event is neutral, gain-or loss-of-function in a tumor sample. The method uses a belief-propagation algorithm to infer gene activity from gene expression and copy number...
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