Article
Latent adenoviral infection induces production of growth factors relevant to airway remodeling in COPD.
American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2004
Ogawa Emiko, Elliott W Mark, Hughes Fiona, Eichholtz Thomas J, Hogg James C, Hayashi Shizu
Abstract excerpt
Previous studies showed an association between latent adenoviral infection with expression of the adenoviral E1A gene and chronic obstructive pulmonary disease (COPD). The present study focuses on how the adenoviral E1A gene could alter expression of growth factors by human bronchial epithelial (HBE) cells. The data show that connective tissue growth factor (CTGF) and transforming growth factor (TGF)-beta 1 mRNA...
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