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Article

Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts.

Arthritis and rheumatism - 1 Dec 2007

Shi-wen Xu, Kennedy Laura, Renzoni Elisabetta A, Bou-Gharios George, du Bois Roland M, Black Carol M, Denton Christopher P, Abraham David J, Leask Andrew

Abstract excerpt

OBJECTIVE: Fibrosis is excessive scarring caused by the accumulation and contraction of extracellular matrix proteins and is a common end pathway in many chronic diseases, including scleroderma (systemic sclerosis [SSc]). Indeed, pulmonary fibrosis is a major cause of death in SSc. Transforming growth factor beta (TGFbeta) induces endothelin 1 (ET-1) in human lung fibroblasts by a Smad-independent, JNK-dependent...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18050250
DOI: 10.1002/art.23134

Genes

CCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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