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Article

Analysis of the factor XI variant Arg184Gly suggests a structural basis for factor IX binding to factor XIa.

Journal of thrombosis and haemostasis : JTH - 1 Jul 2013

Geng Y, Verhamme I M, Sun M F, Bajaj S P, Emsley J, Gailani D

Abstract excerpt

BACKGROUND: A patient with factor XI (FXI) deficiency was reported with an Arg184Gly substitution in the FXI A3 domain. The A3 domain contains an exosite required for binding of FIX to activated FXI (FXIa). OBJECTIVE: To test the effects of the Arg184Gly substitution on FIX activation, and to characterize the FIX-binding site on FXIa. METHODS: Recombinant FXIa and FIX variants were used to identify residues...

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Identifiers

PMID: 23617568
DOI: 10.1111/jth.12275
PMCID: PMC4158700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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