Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.

Biochemical and biophysical research communications - 15 Jan 2016

Honda Makoto, Minami Itsunari, Tooi Norie, Morone Nobuhiro, Nishioka Hisae, Uemura Kengo, Kinoshita Ayae, Heuser John E, Nakatsuji Norio, Aiba Kazuhiro

Abstract excerpt

Cellular disease models are useful tools for Alzheimer's disease (AD) research. Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs), are promising materials for creating cellular models of such diseases. In the present study, we established cellular models of AD in hESCs that overexpressed the mutant Presenilin 1 (PS1) gene with the use of a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Human Embryonic Stem Cells

Share to Mutation

Share to Neurons

Share to Presenilin-1

Share to Up-Regulation

Source

Identifiers

PMID: 26687948
DOI: 10.1016/j.bbrc.2015.12.025

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The modeling of Alzheimer's disease by the overexpression of mutant Presenilin 1 in human embryonic stem cells.PMID 26687948Read ↗

Modeling familial Alzheimer's disease with induced pluripotent stem cells.Semantic proximity Read ↗

Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem CellsSemantic proximity Read ↗

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic PropertiesSemantic proximity Read ↗

Derivation of induced pluripotent stem cells from a familial Alzheimer's disease patient carrying the L282F mutation in presenilin 1.Semantic proximity Read ↗

Establishment of induced pluripotent stem cell line (ZZUi009-A) from an Alzheimer's disease patient carrying a PSEN1 gene mutation.Semantic proximity Read ↗

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s diseaseSemantic proximity Read ↗

Early pathogenic event of Alzheimer's disease documented in iPSCs from patients with PSEN1 mutations.Semantic proximity Read ↗

Alzheimer's disease and synapse Loss: What can we learn from induced pluripotent stem Cells?Semantic proximity Read ↗

Human iPSC-Derived Hippocampal Spheroids: An Innovative Tool for Stratifying Alzheimer Disease Patient-Specific Cellular Phenotypes and Developing Therapies.Semantic proximity Read ↗

Generation of gene-targeted mice using embryonic stem cells derived from a transgenic mouse model of Alzheimer's disease.Semantic proximity Read ↗

Familial Alzheimer's disease-associated PSEN1 mutations affect neurodevelopment through increased Notch signaling.Semantic proximity Read ↗

Generation of a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient carrying an E363Q mutation in PSEN1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.