Article
A Val-25-to-Ile substitution in the envelope precursor polyprotein, gPr80env, is responsible for the temperature sensitivity, inefficient processing of gPr80env, and neurovirulence of ts1, a mutant of Moloney murine leukemia virus TB.
Journal of virology - 1 Feb 1990
Szurek P F, Yuen P H, Ball J K, Wong P K
Abstract excerpt
ts1 is a neurovirulent spontaneous temperature-sensitive mutant of Moloney murine leukemia virus TB which causes hindlimb paralysis in mice. Previously, it had been shown that the temperature-sensitive defect resided in the env gene. At the restrictive temperature, the envelope precursor polyprotein, gPr80env, is inefficiently processed intracellularly into two cleavage products, gp70 and Prp15E. This inefficient...
Topics
- Animals
- Cell Line
- Cells, Cultured
- Gene Expression
- Genes, Viral
- Isoleucine
- Mice
- Mice, Inbred Strains
- Moloney murine leukemia virus
- Mutation
- Nucleic Acid Hybridization