Article
Mutational analysis of residues in the coiled-coil domain of human immunodeficiency virus type 1 transmembrane protein gp41.
Journal of virology - 1 Dec 1998
Weng Y, Weiss C D
Abstract excerpt
The envelope glycoprotein (Env) of human immunodeficiency virus mediates virus entry into cells by undergoing conformational changes that lead to fusion between viral and cellular membranes. A six-helix bundle in gp41, consisting of an interior trimeric coiled-coil core with three exterior helice...
Topics
- Amino Acid Sequence
- Animals
- COS Cells
- Cell Fusion
- Cell Line
- Gene Expression
- Genes, env
- HIV Envelope Protein gp41
- HIV-1
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Protein Conformation
- Protein Structure, Secondary
- Protein Structure, Tertiary
- Repetitive Sequences, Amino Acid
- Virulence