Current Understanding of ALS Onset, Progression and Treatments

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative motor neuron disorder characterized by the loss of motor neurons in the CNS and spinal cord. The number of ALS patients is expected to increase to about 380,000 worldwide by 2040. Current treatments for ALS provide limited benefits, and the exact cause of the disease is still not fully understood. Genetic and environmental factors, such as mutations in gen...

Topics

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• Mutation
• RNA-Binding Protein FUS
• Amyotrophic Lateral Sclerosis
• Amyotrophic Lateral Sclerosis Research
• C9orf72 Protein
• DNA-Binding Proteins
• Genetic Predisposition to Disease
• Superoxide Dismutase-1

Identifiers and source

Literature Corpus work

7a772480-d43d-581f-be31-49c80bf9cac5

DOI

10.14293/pr2199.001277.v1