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Article

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.

Blood - 3 Nov 2011

Li Li, Bailey Emily, Greenblatt Sarah, Huso David, Small Donald

Abstract excerpt

Clinical evidence has shown that FLT3 internal tandem duplication (ITD) mutation confers poor prognosis in acute myeloid leukemia. Loss of the FLT3 wild-type (WT) allele is associated with even worse prognosis. We have previously reported that heterozygous FLT3(wt/ITD) "knockin" mice develop a slowly fatal myeloproliferative neoplasm (MPN). To study the roles of the WT FLT3 and ITD alleles in the development of...

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Source

Open in PubMed Open full text

Identifiers

PMID: 21908433
DOI: 10.1182/blood-2011-01-328096
PMCID: PMC3208299

Genes

FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the wild-type allele contributes to myeloid expansion and disease aggressiveness in FLT3/ITD knockin mice.PMID 21908433Read ↗

Impact of gene dosage, loss of wild-type allele, and FLT3 ligand on Flt3-ITD-induced myeloproliferation.Semantic proximity Read ↗

Knock-in of an internal tandem duplication mutation into murine FLT3 confers myeloproliferative disease in a mouse model.Semantic proximity Read ↗

Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemiasSemantic proximity Read ↗

Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model.Semantic proximity Read ↗

FLT3-ITD knockin impairs hematopoietic stem cell quiescence/homeostasis, leading to myeloproliferative neoplasm.Semantic proximity Read ↗

NPMc+ cooperates with Flt3/ITD mutations to cause acute leukemia recapitulating human disease.Semantic proximity Read ↗

Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study.Semantic proximity Read ↗

Mutant FLT3 signaling contributes to a block in myeloid differentiationSemantic proximity Read ↗

Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.Semantic proximity Read ↗

FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model.Semantic proximity Read ↗

FLT3 internal tandem duplication mutations induce myeloproliferative or lymphoid disease in a transgenic mouse model.Semantic proximity Read ↗

Knock-in of a FLT3/ITD mutation cooperates with a NUP98-HOXD13 fusion to generate acute myeloid leukemia in a mouse model.Semantic proximity Read ↗

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