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Mouse Genetic Analysis of Bone Marrow Stem Cell Niches: Technological Pitfalls, Challenges, and Translational Considerations

19 Oct 2017

Abstract excerpt

The development of mouse genetic tools has made a significant contribution to the understanding of skeletal and hematopoietic stem cell niches in bone marrow (BM). However, many experimental designs (e.g., selections of marker genes, target vector constructions, and choices of reporter murine strains) have unavoidable technological limitations and bias, which lead to experimental discrepancies, data...

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Share to Epigenetics and DNA Methylation
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PMID: 29056332
DOI: 10.1016/j.stemcr.2017.09.014

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