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Article

Regulatory regions of the paraoxonase 1 (PON1) gene are associated with neovascular age-related macular degeneration (AMD).

Age (Dordrecht, Netherlands) - 1 Oct 2013

Oczos Jadwiga, Grimm Christian, Barthelmes Daniel, Sutter Florian, Menghini Moreno, Kloeckener-Gruissem Barbara, Berger Wolfgang

Abstract excerpt

Physiological stress response and oxidative damage are factors for aging processes and, as such, are thought to contribute to neovascular age-related macular degeneration (AMD). Paraoxonase 1 (PON1) is an enzyme that plays an important role in oxidative stress and aging. We investigated association of DNA sequence variants (SNP) within the upstream regulatory region of the PON1 gene with neovascular AMD in 305...

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Source

Open in PubMed Open full text

Identifiers

PMID: 22956172
DOI: 10.1007/s11357-012-9467-x
PMCID: PMC3776091

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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