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Article

APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus.

Journal of neurology, neurosurgery, and psychiatry - 1 Nov 2012

Pyykkö Okko T, Helisalmi Seppo, Koivisto Anne M, Mölsä Juhani A A, Rummukainen Jaana, Nerg Ossi, Alafuzoff Irina, Savolainen Sakari, Soininen Hilkka, Jääskeläinen Juha E, Rinne Jaakko, Leinonen Ville, Hiltunen Mikko

Abstract excerpt

OBJECTIVE: To investigate the association of apolipoprotein E (APOE) genotype, especially the APOE4 allele, to (1) idiopathic normal pressure hydrocephalus (iNPH) and (2) amyloid-β (Aβ) plaques in cortical brain biopsies of presumed NPH patients with and without a final clinical diagnosis of Alzheimer's disease (AD). METHODS: 202 patients with presumed NPH were evaluated by intraventricular pressure monitoring...

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Source

Identifiers

PMID: 22955176
DOI: 10.1136/jnnp-2011-303849

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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