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Article

Alzheimer's Disease-Related Polymorphisms in Shunt-Responsive Idiopathic Normal Pressure Hydrocephalus.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Huovinen Joel, Helisalmi Seppo, Paananen Jussi, Laiterä Tiina, Kojoukhova Maria, Sutela Anna, Vanninen Ritva, Laitinen Marjo, Rauramaa Tuomas, Koivisto Anne M, Remes Anne M, Soininen Hilkka, Kurki Mitja, Haapasalo Annakaisa, Jääskeläinen Juha E, Hiltunen Mikko, Leinonen Ville

Abstract excerpt

BACKGROUND: Idiopathic normal pressure hydrocephalus (iNPH) is a late onset, surgically treated progressive brain disease caused by impaired cerebrospinal fluid dynamics and subsequent ventriculomegaly. Comorbid Alzheimer's disease (AD) seems to be frequent in iNPH. OBJECTIVE: We aim to evaluate the role of AD-related polymorphisms in iNPH. METHODS: Overall 188 shunt-operated iNPH patients and 688 controls...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28984604
DOI: 10.3233/JAD-170583

Genes

NME8
ABCA7
APOE
CASS4
CELF1
CLU
DSG2
EPHA1
FERMT2
PICALM
SORL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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