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Article

Novel envelope determinants for CCR3 use by human immunodeficiency virus.

Journal of virology - 1 Nov 2006

Aasa-Chapman Marlén M I, Seymour Craig R, Williams Ian, McKnight Aine

Abstract excerpt

Human immunodeficiency virus type 1 can generally use CCR3 and CCR5 for cell entry. We show that envelopes with novel phenotypes arise during "coreceptor switch": one loses the ability to use CCR3 (R5-only phenotype), and another gains use of CXCR4 in addition to CCR5 and CCR3 (R3/R5/X4-using phenotype). The envelope determinants for CCR3 use mapped to three amino acids. One, N356 in conserved region 3, is a...

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Source

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Identifiers

PMID: 17041228
DOI: 10.1128/JVI.01030-06
PMCID: PMC1641764

Genes

CCR3
CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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