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Article

Phenotypic and genotypic comparisons of CCR5- and CXCR4-tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals.

Journal of virology - 1 Mar 2004

Pollakis Georgios, Abebe Almaz, Kliphuis Aletta, Chalaby Moustapha I M, Bakker Margreet, Mengistu Yohannes, Brouwer Margreet, Goudsmit Jaap, Schuitemaker Hanneke, Paxton William A

Abstract excerpt

Individuals infected with human immunodeficiency virus type 1 (HIV-1) subtype C infrequently harbour X4 viruses. We studied R5 and X4 biological clones generated from HIV-1 subtype C-infected individuals. All subtype C R5 viruses demonstrated slower profiles of replication on CD4(+) lymphocytes in comparison to subtype B viruses, whereas subtype C X4 viruses replicated with comparable efficiency to subtype B X4...

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Share to Cells, Cultured
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

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Share to Receptors, CCR5

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Share to Sequence Analysis, DNA

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Source

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Identifiers

PMID: 14990703
DOI: 10.1128/jvi.78.6.2841-2852.2004
PMCID: PMC353763

Genes

CCR5
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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