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Article

Focal adhesion targeting: the critical determinant of FAK regulation and substrate phosphorylation.

Molecular biology of the cell - 1 Aug 1999

Shen Y, Schaller M D

Abstract excerpt

The focal adhesion kinase (FAK) is discretely localized to focal adhesions via its C-terminal focal adhesion-targeting (FAT) sequence. FAK is regulated by integrin-dependent cell adhesion and can regulate tyrosine phosphorylation of downstream substrates, like paxillin. By the use of a mutational strategy, the regions of FAK that are required for cell adhesion-dependent regulation and for inducing tyrosine...

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Source

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Identifiers

PMID: 10436008
DOI: 10.1091/mbc.10.8.2507
PMCID: PMC25482

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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