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Article

Low levels of chromosomal mutations in germ cells derived from doxorubicin-treated stem spermatogonia in the mouse.

Cancer research - 15 Jan 1990

Meistrich M L, van Beek M E, Liang J C, Johnson S L, Lu J

Abstract excerpt

The mutagenic effects of doxorubicin (Adriamycin, ADR) on mouse spermatogonial stem cells were examined by analysis of spermatocyte chromosomes and of dominant lethality transmitted through the spermatozoa. The effects of ADR on mutations, cytotoxicity, and sperm head abnormalities were compared with those of radiation. The cytotoxic effect of 6 Gy of gamma-radiation on stem spermatogonia was equivalent to about...

Topics

Animals
Chromosome Aberrations
Doxorubicin
Male
Mice
Mice, Inbred C3H
Mutation
Sperm Head
Spermatogonia
Spermatozoa

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2295076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2295076-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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