Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mouse

13 Mar 2001

Abstract excerpt

Etoposide, a topoisomerase II inhibitor widely used in cancer therapy, is suspected of inducing secondary tumors and affecting the genetic constitution of germ cells. A better understanding of the potential heritable risk of etoposide is needed to provide sound genetic counseling to cancer patients treated with this drug in their reproductive years. We used a mouse model to investigate the effects of clinical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer therapeutics and mechanisms
Share to Lung Cancer Research Studies
Share to Testicular diseases and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11274416
DOI: 10.1073/pnas.061404598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Etoposide induces heritable chromosomal aberrations and aneuploidy during male meiosis in the mousePMID 11274416Read ↗

Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogoniaSemantic proximity Read ↗

Unlike other chemicals, etoposide (a topoisomerase-II inhibitor) produces peak mutagenicity in primary spermatocytes of the mouse.Semantic proximity Read ↗

Risks of genetic damage in offspring conceived using spermatozoa produced during chemotherapy or radiotherapySemantic proximity Read ↗

Epigenetic Alterations in Sperm DNA Associated with Testicular Cancer TreatmentSemantic proximity Read ↗

Relative Susceptibilities of Male Germ Cells to Genetic Defects Induced by Cancer ChemotherapiesSemantic proximity Read ↗

Meiotic interstrand DNA damage escapes paternal repair and causes chromosomal aberrations in the zygote by maternal misrepairSemantic proximity Read ↗

Mechanisms and consequences of paternally-transmitted chromosomal abnormalities.Semantic proximity Read ↗

Paternally Transmitted Chromosomal Aberrations in Mouse Zygotes Determine Their Embryonic Fate1Semantic proximity Read ↗

Exposure to anticancer drugs can result in transgenerational genomic instability in miceSemantic proximity Read ↗

Induction of aneuploidy in male mouse germ cells detected by the sperm–FISH assay: a review of the present data baseSemantic proximity Read ↗

Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells.Semantic proximity Read ↗

Effects of Four Chemotherapeutic Agents, Bleomycin, Etoposide, Cisplatin, and Cyclophosphamide, on DNA Damage and Telomeres in a Mouse Spermatogonial Cell Line1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.