Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemotherapy induced damage to spermatogonial stem cells in prepubertal mouse in vitro impairs long-term spermatogenesis

26 Dec 2020

Abstract excerpt

Chemotherapy can affect testis development of young boys with cancer, reducing the chances of fatherhood in adulthood. Studies using experimental models are needed to determine the damage caused by individual chemotherapy drugs in order to predict the risk of infertility and direct patients towards appropriate fertility preservation options. Here, we investigated the individual role of two drugs, cisplatin and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemotherapy-induced organ toxicity mitigation
Share to Reproductive Biology and Fertility
Share to Sperm and Testicular Function

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33425685
DOI: 10.1016/j.toxrep.2020.12.023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemotherapy induced damage to spermatogonial stem cells in prepubertal mouse in vitro impairs long-term spermatogenesisPMID 33425685Read ↗

Chemotherapy drugs cyclophosphamide, cisplatin and doxorubicin induce germ cell loss in an in vitro model of the prepubertal testisSemantic proximity Read ↗

Recovery of Spermatogenesis Following Cancer Treatment with Cytotoxic Chemotherapy and RadiotherapySemantic proximity Read ↗

Protective effect of melatonin on alleviating early oxidative stress induced by DOX in mice spermatogenesis and sperm quality maintainingSemantic proximity Read ↗

Cisplatin Induces Apoptosis in Mouse Neonatal Testes Organ CultureSemantic proximity Read ↗

Cisplatin‐Induced Long‐term Failure of Spermatogenesis in Adult C57/Bl/6J MiceSemantic proximity Read ↗

Effects of Four Chemotherapeutic Agents, Bleomycin, Etoposide, Cisplatin, and Cyclophosphamide, on DNA Damage and Telomeres in a Mouse Spermatogonial Cell Line1Semantic proximity Read ↗

Mesenchymal stem cells promote spermatogonial stem/progenitor cell pool and spermatogenesis in neonatal mice in vitroSemantic proximity Read ↗

Spermatogonial Stem Cells for In Vitro Spermatogenesis and In Vivo Restoration of FertilitySemantic proximity Read ↗

Development of Postmeiotic Cells In Vitro from Spermatogonial Cells of Prepubertal Cancer PatientsSemantic proximity Read ↗

Suppression of transforming growth factor-beta signaling enhances spermatogonial proliferation and spermatogenesis recovery following chemotherapySemantic proximity Read ↗

Testicular function in cultured postnatal mouse testis fragments is similar to that of animals during the first wave of spermatogenesisSemantic proximity Read ↗

Very Small Embryonic-Like Stem Cells Survive and Restore Spermatogenesis after Busulphan Treatment in Mouse TestisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.