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Article

Etoposide induces chromosomal abnormalities in mouse spermatocytes and stem cell spermatogonia

25 Nov 2005

Abstract excerpt

BACKGROUND: Etoposide (ET) is a chemotherapeutic agent widely used in the treatment of leukaemia, lymphomas and many solid tumours such as testicular and ovarian cancers, all of which are common in patients of reproductive age. The purpose of the study was to characterize the long-term effects of ET on male germ cells using sperm fluorescence in situ hybridization (FISH) analyses. METHODS: Chromosomal aberrations...

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PMID: 16311288
DOI: 10.1093/humrep/dei416

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Source receipt: pubmed, retrieved 7 Sept 2026.

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