Article
Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila.
Proceedings of the National Academy of Sciences of the United States of America - 18 Sept 2012
Ayukawa Tomonori, Matsumoto Kenjiroo, Ishikawa Hiroyuki O, Ishio Akira, Yamakawa Tomoko, Aoyama Naoki, Suzuki Takuya, Matsuno Kenji
Abstract excerpt
Notch (N) is a transmembrane receptor that mediates cell-cell interactions to determine many cell-fate decisions. N contains EGF-like repeats, many of which have an O-fucose glycan modification that regulates N-ligand binding. This modification requires GDP-L-fucose as a donor of fucose. The GDP-L-fucose biosynthetic pathways are well understood, including the de novo pathway, which depends on GDP-mannose 4,6...
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