Article
Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila.
Science signaling - 20 Dec 2011
Mariappa Daniel, Sauert Kathrin, Mariño Karina, Turnock Daniel, Webster Ryan, van Aalten Daan M F, Ferguson Michael A J, Müller H-Arno J
Abstract excerpt
Glycosylation is essential for growth factor signaling through N-glycosylation of ligands and receptors and the biosynthesis of proteoglycans as co-receptors. Here, we show that protein O-GlcNAcylation is crucial for fibroblast growth factor (FGF) signaling in Drosophila. We found that nesthocker (nst) encodes a phosphoacetylglucosamine mutase and that nst mutant embryos exhibited low amounts of intracellular...
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