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Article

The balance between GMD and OFUT1 regulates Notch signaling pathway activity by modulating Notch stability.

Biological research - 1 Jan 2011

Glavic Alvaro, López-Varea Ana, de Celis José F

Abstract excerpt

The Notch signaling pathway plays an important role in development and physiology. In Drosophila, Notch is activated by its Delta or Serrate ligands, depending in part on the sugar modifications present in its extracellular domain. O-fucosyltransferase-1 (OFUT1) performs the first glycosylation step in this process, O-fucosylating various EGF repeats at the Notch extracellular domain. Besides its...

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PMID: 21720678
DOI: 10.4067/S0716-97602011000100004

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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