Article
HTRA1 expression profile and activity on TGF-β signaling in HTRA1 mutation carriers.
Journal of cellular physiology - 1 Oct 2020
Fasano Alessandro, Formichi Patrizia, Taglia Ilaria, Bianchi Silvia, Di Donato Ilaria, Battisti Carla, Federico Antonio, Dotti Maria Teresa
Abstract excerpt
High temperature requirement A1 (HTRA1) is a serine protease playing a modulatory role in various cell processes, particularly in the regulation of transforming growth factor-β (TGF-β) signaling. A deleterious role in late-onset cerebral small vessel diseases (CSVDs) of heterozygous HTRA1 mutations, otherwise causative in homozygosity of cerebral autosomal recessive arteriopathy with subcortical infarcts and...
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