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Article

HtrA1 serine protease inhibits signaling mediated by Tgfβ family proteins

18 Feb 2004

Abstract excerpt

HtrA1, a member of the mammalian HtrA serine protease family, has a highly conserved protease domain followed by a PDZ domain. Because HtrA1 is a secretory protein and has another functional domain with homology to follistatin, we examined whether HtrA1 functions as an antagonist of Tgfbeta family proteins. During embryo development, mouse HtrA1 was expressed in specific areas where signaling by Tgfbeta family...

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PMID: 14973287
DOI: 10.1242/dev.00999

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